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Gut Microbes Linked to Obesity

Researchers have uncovered 26 bacterial species found in the human gut that are linked to insulin resistance, high blood pressure, and other conditions associated with obesity, reports The Baltimore Sun.

Researchers led by Claire Fraser at the University of Maryland School of Medicine report in PLOS One on their characterization of the gut microbiota of 310 men and women belonging to the Old Order Amish sect. From that, they identified three communities of bacteria — similar to previously reported enterotypes — though the researchers note that neither BMI nor metabolic syndrome traits were linked to any of those communities. Then using network analysis, researchers identified the 26 bacteria correlated with metabolic syndrome. Those bacteria mainly belong to the Bacteroidetes and Firmicutes phyla, and make up part of the core gut microbiome of the Amish.

"We can't infer cause or effect, but now that we have results from step one and we can now look at what the bacteria are doing, it can give us more information to go about getting an intervention," Maryland's Brandi Cantarel tells the Sun.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.