Here's something that will make you long for the good old days: five years ago, getting grant funding seemed like a major challenge. In our May 2004 issue of Genome Technology — just after then-NIH Director Elias Zerhouni had succeeded in doubling the agency's budget — we devoted our cover story to offering advice on writing and winning grants, and we profiled a number of program directors who could offer their assistance to readers.

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The new Riken president outlines some of his plans for the institute.

The Guardian discusses whether big science projects are worth the loss of resources available for other scientific pursuits.

An NEJM update from the ClinVar team highlights the difficulties of interpreting genetic variants.

In Nature this week: genomic analysis of high-grade serous ovarian cancer, and more.