NEW YORK (GenomeWeb) – Scientists from the UK have exploited single nucleotide polymorphisms in alleles that cause corneal dystrophy to edit the genes using CRISPR/Cas9.

While CRISPR/Cas9 genome editing can be programmed to target many sections of the genome, the technique will only make a double-stranded break if the guide RNA matches up next to a three-base-pair section called a protospacer adjacent motif (PAM). For Cas9 enzymes from Streptococcus pyogenes commonly used in genome editing applications, PAMs take the form of NGG.

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