NEW YORK (GenomeWeb) – An international team of researchers has connected rare coding variants in three microglial-expressed genes to Alzheimer's disease risk.

While some 30 genetic loci have been associated with risk of developing late-onset Alzheimer's disease, those loci only explain a portion of disease risk. To uncover rare variants that may also contribute to Alzheimer's disease risk, researchers led by the University of Pennsylvania's Gerard Schellenberg conducted a three-stage case-control study drawing on data from more than 85,000 people.

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