NEW YORK (GenomeWeb) – An international team of researchers has connected rare coding variants in three microglial-expressed genes to Alzheimer's disease risk.

While some 30 genetic loci have been associated with risk of developing late-onset Alzheimer's disease, those loci only explain a portion of disease risk. To uncover rare variants that may also contribute to Alzheimer's disease risk, researchers led by the University of Pennsylvania's Gerard Schellenberg conducted a three-stage case-control study drawing on data from more than 85,000 people.

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Senator Elizabeth Warren (D-Mass.) has released the results of a genetic ancestry analysis, the Boston Globe reports.

Retraction Watch's Ivan Oransky and Adam Marcus report that Harvard Medical School and Brigham and Women's Hospital have recommended that more than 30 papers from a former researcher be retracted.

Thomas Steitz, who won the 2009 chemistry Nobel Prize for his ribosome work, has died, the Washington Post reports.

In PLOS this week: mechanisms for genes implicated in coronary artery disease, rumen microbes and host genetics influence cow methane production, and more.