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NEW YORK (GenomeWeb) – A rare loss-of-function mutation found among Old Order Amish individuals protects against some of the effects of aging, a new study has found.

The mutation, located in the SERPINE1 gene, affects the function of plasminogen activator inhibitor-1 (PAI-1), which has a role in cellular senescence and is expressed at higher levels in senescent cells, leading the researchers to suspect that variants in this gene could influence aging and cardiometabolic disease, which affect lifespan.

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Gene editing could be an issue competitive sports need to address soon, four researchers from Arizona State University write at Slate.

A genetic alteration appears to increase heart failure risk among people of African descent, according to the Washington Post.

In his look back at the past decade, BuzzFeed News' Peter Aldhous writes that direct-to-consumer genetic testing has led to "Facebook for genes."

In Nature this week: genetic "clock" that can predict the lifespans of vertebrates, new assembler called wtdbg2, and more.

Jan
28
Sponsored by
Sophia Genetics

This webinar will discuss how Moffitt Cancer Center has implemented a new capture-based application to accurately assess myeloid malignancies by detecting complex variants in challenging genes in a single experiment.