NEW YORK (GenomeWeb) – A rare loss-of-function mutation found among Old Order Amish individuals protects against some of the effects of aging, a new study has found.

The mutation, located in the SERPINE1 gene, affects the function of plasminogen activator inhibitor-1 (PAI-1), which has a role in cellular senescence and is expressed at higher levels in senescent cells, leading the researchers to suspect that variants in this gene could influence aging and cardiometabolic disease, which affect lifespan.

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