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Polygenic Modifiers of Pathogenic Genes May Refine Disease Risk Prediction

Dec 05, 2019
|
Christie Rizk
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NEW YORK – Researchers at Massachusetts General Hospital, Color, and elsewhere have determined that polygenic factors can significantly modify the risk conferred by monogenic risk variants for breast cancer, colon cancer, or coronary artery disease, and are exploring the best ways to implement a combined monogenic/polygenic risk score into patient care.

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