NEW YORK (GenomeWeb News) – The National Heart, Lung, and Blood Institute plans to request applications for a program that will build on existing genome-wide association study data by adding new information about molecular and cellular profiles, as well as disease phenotypes.
The "Next Generation Association Studies" grant, which NHLBI expects to publish in the spring of 2010, will support two types of proposals.
The first grants will fund technology development aimed at finding ways to use pluripotent stem cell generation and differentiation at the level of population samples. The second line will apply cellular reprogramming and molecular profiling to population-based samples and will integrate the information from such studies into existing genotypic and phenotypic data.
The data from these studies will be used to assess how genetic variation influences biological networks in cell-based disease models.
Research proposals aiming to conduct both lines of studies should have a multidisciplinary approach, including epidemiologists, clinicians, population geneticists, stem cell and molecular biologists, and bioinformaticians.