NEW YORK (GenomeWeb) – Some innate immune system genes have evolved rapidly and vary widely in their expression across species and individual cells, while others are more conserved and consistent, according to a new study.

The innate immune response kicks into gear upon infection to both inhibit pathogen replication and raise the alarm. This response has to balance its rapid evolution in the face of pathogens and cell-to-cell variability with the need for regulatory constraints to prevent tissue damage and other pathological effects.

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