NEW YORK (GenomeWeb) – The Alzheimer's disease risk variant APOE4 leads to a number of changes within brain cells, including differences in gene expression, according to a new study.

People with the apolipoprotein E4 variant have a higher risk of developing late-onset Alzheimer's disease — the variant is three times more common among people with the condition than the general public. But while APOE4 has clearly been linked to higher levels of the amyloid protein that forms plaques seen in patients' brains, it's been unclear how this increase takes place.

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