NEW YORK (GenomeWeb) – The Alzheimer's disease risk variant APOE4 leads to a number of changes within brain cells, including differences in gene expression, according to a new study.

People with the apolipoprotein E4 variant have a higher risk of developing late-onset Alzheimer's disease — the variant is three times more common among people with the condition than the general public. But while APOE4 has clearly been linked to higher levels of the amyloid protein that forms plaques seen in patients' brains, it's been unclear how this increase takes place.

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An analysis of UK Biobank data finds hemochromatosis to be more prevalent than thought, according to the BBC.

An analysis finds that female biomedical researchers receive fewer prizes than male ones, and when they do win prizes, they are less prestigious.

Federal researchers tell the Los Angeles Times that the shutdown is causing missed research opportunities as they try to keep their experiments going.

In Nature this week: improved genomic analysis using a graph genome reference, tumor mutational burden could predict clinical response to immune checkpoint inhibitors, and more.

Feb
21
Sponsored by
L7 Informatics

This webinar will provide a first-hand look at how Gradalis, a clinical-stage immunotherapy developer, is using an information management solution from L7 to streamline its research, clinical, and manufacturing operations.

Feb
26
Sponsored by
Advanced Cell Diagnostics

This webinar will demonstrate how a research team at the Firestone Institute for Respiratory Health at McMaster University developed a cellular and molecular phenotyping pipeline using archived samples of lung tissue derived from patients diagnosed with fibrotic interstitial lung disease.