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NEW YORK – Genome-wide polygenic risk scores are more predictive of coronary heart disease in three US racial or ethnic groups than restricted polygenic risk scores, a new study has found. 

Scores of genetic loci have been linked to the risk of developing coronary heart disease (CHD), and researchers have used these to generate polygenic risk scores to predict coronary events. But as these scores largely have been developed in cohorts of European ancestry, their utility among other ancestry groups has not been clear.

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