Genetic Research

News on genome-wide association studies, genotyping, metagenomics, basic research in genetics, genomics, and molecular diagnostics.

New male pattern baldness candidates turned up in an analysis of more than 70,000 individuals, including UK Biobank participants profiled for a prior baldness GWAS.

Regeneron Pharmaceuticals

Since 2015, the Regeneron Genetics Center has sequenced 250,000 exomes from phenotyped individuals, identifying "human knockouts" and other large-effect mutations.

A null mutation in the SERPINE1 gene was associated with longer telomeres and increased longevity among carriers, a new study found.

Gut microbiome researchers have identified features associated with everything from Crohn's disease to salt intake, immune activity, and hypertension.

In a study of nearly 45,000 people, researchers found that two variants in LPA each increase aortic stenosis risk by about a third, and about twofold in combination.

The US Food and Drug Administration has new guidelines that enable some gene and cell therapies to undergo expedited review, according to the New York Times.

Using gene drives to control invasive species might be too risky, an initial advocate of the approach says.

In Science this week: intellectual property experts argue patent battles such as the one over CRISPR are wasteful, and more.

Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.