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USPTO Publishes One RNAi-Related Patent, May 2008

Title: Fc Gamma RIIA-Specific Nucleic Acid Interference
Number: 7,368,559
Filed: Nov. 15, 2004
Lead Inventor: Diana Beardsley, Yale University
The invention “provides methods and compositions for attenuating expression of Fc gamma RIIA,” according to the patent’s abstract. “In general, the described methodology involves the use of RNAi constructs that are targeted to a Fc gamma RIIA mRNA sequence.”

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.