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NEW YORK (GenomeWeb) – Startup Genetics Research is developing a sample prep approach that's turning the traditional concept of finding a needle in a haystack on its head.   

"We protect the needle, and then burn the haystack down," said Anthony Shuber, the company's president and chief operating officer.

Essentially, the company's negative enrichment technology uses CRISPR nucleases to protect a region of interest on a strand of DNA and then degrades the surrounding material, until the target fragments are all that are left to be sequenced and analyzed.

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