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NEW YORK (GenomeWeb) – Scientists from the University of California, San Diego and UC-Irvine have created a proof-of-concept, CRISPR/Cas9-based gene drive to genetically modify entire populations of the malaria-carrying mosquito Anopheles stephensi.

Led by co-first authors Valentino Gantz of UCSD and Nijole Jasinskiene of UC-Irvine, and senior authors Ethan Bier and Anthony James of UC-Irvine, the scientists adapted a mutagenic chain reaction gene drive to spread genes conferring resistance to the malaria parasite Plasmodium falciparum.

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