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New Products: Sigma's Mission miRNA Inhibitors

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Sigma Life Sciences has introduced Mission synthetic and lentiviral microRNA inhibitors for the long-term suppression of any endogenous human and mouse miRNA.

According to the company, the inhibitors are based on tough decoys, which are double-stranded RNAs with a stem-loop stabilized secondary structure, which helps prevent cellular nuclease degradation and enables sustained miRNA inhibition for over one month.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.