New CRISPR/Cas9-based Tech Edits Single Nucleotides Without Breaking DNA

Apr 20, 2016

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NEW YORK (GenomeWeb) – By fusing a nucleotide-flipping enzyme to Cas9, scientists from Harvard University have developed a new way to edit point mutations without making a double-stranded break. Though presently limited in which base conversions it can make, the technique could reduce the effect of unwanted indels in gene editing and could be applied to correct mutations associated with genetic diseases.

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