Title: Synthetic Genes and Genetic Constructs
Patent Number: 8,048,670
Filed: Jan. 15, 2004
Lead Inventor: Michael Graham, Commonweath Scientific and Industrial Research Organization (Benitec)
The invention, the patent's abstract states, “relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue, or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the … invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.”
Title: RNAi-Mediated Inhibition of Spleen Tyrosine Kinase-Related Inflammatory Conditions
Patent Number: 8,048,863
Filed: April 13, 2007
Lead Inventor: John Yanni, Alcon
The invention, the patent's abstract states, comprises “RNA interference … for inhibition of spleen tyrosine kinase mRNA expression, in particular, for treating patients having a Syk-related inflammatory condition or at risk of developing a Syk-related inflammatory condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, allergy, or mast-cell disease.”
Title: Mediated Cellular Delivery of LNA Oligonucleotides
Patent Number: 8,048,998
Filed: Jan. 18, 2008
Lead Inventor: Soeren Vestergaard Rasmussen, Exiqon
The invention, the patent's abstract states, “relates to novel modified oligomeric compounds and to methods of making and using such compounds. The invention further relates to methods of enhancing the cellular uptake of oligomeric compounds comprising conjugating a metal chelator to those.”
Title: Construction of Protein-Responsive shRNA/RNAi Control System Using RNP Motif
Application Number: 20110263026
Filed: Dec. 9, 2009
Lead Inventor: Tan Inoue, Japan Science and Technology Agency
The invention, the patent application's abstract states, comprises an “RNAi control system using an RNA-protein interaction motif,” as well as an shRNA composed of a guide strand, a passenger strand, and “a linker strand” made up of an RNP-derived protein-binding motif sequence.
Title: Delivery of Agents Using Interfering Nanoparticles
Application Number: 20110263514
Filed: March 16, 2011
Inventor: Tariq Rana, Sanford-Burnham Medical Research Institute
The patent application, its abstract states, claims “compositions and methods for delivery of therapeutic agents, such as chemically stabilized antisense oligonucleotides useful in RNA silencing. The compositions include interfering nanoparticles associated with one or more agents. Several functional iNOP derivatives are provided [that] allow for targeted delivery of agents to specific cell types as well as exhibiting reduced cellular toxicity.”
Title: Small Interfering RNA for Gene Knockdown of the Subcutaneous N-Methyl-D-Aspartate Receptor NR1 Subunit and Its Application of Pharmaceutics
Application Number: 20110263676
Filed: May 14, 2010
Inventor: Ping-Heng Tan, I-Shou University
The invention comprises a “small interfering RNA for gene knockdown of the N-methyl-D-aspartate receptor NR1 subunit,” as well as “a method of … applying the small interfering RNA on subcutaneous tissues [to temporarily] interfere with the genetic expression of the NMDA receptor NR1 subunit in the hypoderm,” the patent application's abstract states.
The siRNA can be used to moderate “inflammatory pain or intolerable chronic pain, especially on clinical chronic pain and burn ... patients,” it adds.
Title: Reduced Size Self-Delivering RNAi Compounds
Application Number: 20110263680
Filed: March 23, 2011
Lead Inventor: Anastasia Khvorova, RXi Pharmaceuticals
The invention relates to “RNAi constructs with minimal double-stranded regions, and their use in gene silencing,” the patent application's abstract states. “RNAi constructs associated with the invention include a double-stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing. The RNAi constructs may be, for instance, miRNA constructs that are miRNA modulators.”
Title: RNA Interference-Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid
Application Number: 20110263683
Filed: May 11, 2011
Lead Inventor: Leonid Beigelman, Merck
The invention, the patent application's abstract states, “concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules ... capable of mediating RNA interference against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.”