Title: Methods for Diagnosing Lung Cancer using microRNAs
Patent Number: 8,580,500
Filed: Feb. 28, 2012
Lead Inventor: Carlo Croce, Ohio State University
The invention, the patent's abstract states, provides "novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis."
Title: Inhibitory RNA for Modulating the Molecular Function of ZFAT Gene
Patent Number: 8,580,562
Filed: Sept. 8, 2008
Lead Inventor: Senji Shirasawa, Fukuoka University
The invention, the patent's abstract states, relates to an siRNA between 23 and 27 nucleotides that inhibits the expression of ZFAT in order to decrease cell proliferation of cancer cells, induce apoptosis of cancer cells, or inhibit an immunoresponse. "The inhibitory RNA of this invention is useful for development of molecular target agents particularly for cancer cells or immunosuppressive agents."
Title: Genetic Inhibition by Double-Stranded RNA
Patent Number: 8,580,754
Filed: Oct. 1, 2007
Lead Inventor: Andrew Fire, Carnegie Institution of Washington
The patent, its abstract states, claims "a process … of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical."
Title: Short Oligomer Antagonist Compounds for the Modulation of Target mRNA
Patent Number: 8,580,756
Filed: March 19, 2008
Lead Inventor: Jens Bo Rode Hansen, Santaris Pharma
The invention provides "LNA gapmer oligomers of between 10 [and] 20 nucleobases in length, which have a total of [one to three] phosphodiester internucleoside linkages," the patent's abstract states. "Such oligomers have been found to have superior bioavailability and have also been found to selectively accumulate in kidney cells."
Title: Anti-hepatitis C Virus Composition
Patent Number: 8,580,759
Filed: Aug. 28, 2009
Lead Inventor: Kohji Moriishi, Osaka University
The invention provides an "anti-hepatitis C virus composition that includes a substance that suppresses the expression or function of a PA28-gamma gene, a method for preventing hepatitis C viral infection or suppressing hepatitis C virus growth that includes the step of administering the composition to a subject, and a method for screening an effective component of an anti-hepatitis C virus composition that includes the step of selecting a substance that inhibits the expression or function of a PA28-gamma gene," according to the patent's abstract.
The patent specifically claims an siRNA or shRNA that inhibits PA28-gamma.
Title: Multi-conjugate of siRNA and Preparing Method Thereof
Patent Number: 8,580,946
Filed: April 29, 2009
Lead Inventor: Tae Gwan Park, Korea Advanced Institute of Science and Technology
The invention, the patent's abstract states, relates to a "multi-conjugate of siRNA prepared by direct binding of double-stranded sense/antisense siRNA monomers or indirect covalent bonding mediated by a cross-linking agent or a polymer, and a preparing method of the same. The preparing method of an siRNA multi-conjugate … is characterized by simple and efficient reaction and thereby the prepared siRNA multi-conjugate … has high molecular weight multiple times the conventional siRNA, so that it has high negative charge density, suggesting that it has excellent ionic interaction with a cationic gene carrier, and high gene delivery efficiency."
Title: Methods and Materials for Conferring Resistance to Pests and Pathogens of Plants
Patent Number: 8,581,039
Filed: June 28, 2011
Inventor: Charles Niblett, Venganza
The patent, its abstract states, claims "methods and materials for conferring pest resistance to plants. … Plants are transformed with a silencing construct homologous to a gene of a plant pest that is essential for the survival, development, or pathogenicity of the pest. This results in the plant producing RNAi to the selected gene, which, when ingested by the pest results in silencing of the gene and a subsequent reduction of the pest's ability to harm the plant. In other embodiments, the pest's reduced ability to harm the plant is passed on to pest progeny."