Improved Cytosine Base Editing Tech Eliminates Problem of Undesired Bystander Mutations

NEW YORK – Researchers in the US and China have developed a new, more precise cytosine base editor (CBE) that eliminates the problem of bystander mutations, while increasing the percentage of perfectly modified alleles more than 6,000-fold for disease correction and more than 600-fold for disease modeling compared with the currently available base editor, BE4max.