NEW YORK (GenomeWeb) – A team from Harvard Medical School this week published the details of a novel approach to drug-target screening, combining the genome-editing technology CRISPR and the gene-silencing technology RNAi to identify three genes that appear to be essential to the growth of tumor cells but not normal cells.

According to the researchers, the method offers a number of advantages over conventional RNAi screening, which is limited by incomplete transfection, partial knockdown, and off-target effects, and therefore often requires secondary screening.

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