NEW YORK (GenomeWeb) – In an effort to cut down on unintended consequences of CRISPR/Cas9 gene editing, scientists from Harvard Medical School have combined two strategies known to reduce off-target enzyme activity.

Led by Nicolas Wyvekens and Shengdar Tsai, the researchers looked at the effects of combining dimerizing RNA-guided Fok1-dCas9 fusion nucleases (RFNs) with truncated guide RNAs (tru-RNAs). They published their results yesterday in Human Gene Therapy.

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Chinese state news agency Xinhua reports that a preliminary investigation has found He Jiankui performed his gene-editing work illegally.

John Mendelsohn, a former president of the University of Texas MD Anderson Cancer Center, has died, the New York Times reports.

Identical twins receive different estimates of ancestry from the same direct-to-consumer genetic testing firms, CBC reports.

In PNAS this week: chromosomal features of maize, adaptations in the vinous-throated parrotbill, and more.

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