NEW YORK (GenomeWeb) – No longer just a genomic editing tool, CRISPR/Cas9 can also edit the epigenome, according to a study published today in Nature Biotechnology.

By fusing a non-cutting dCas9 protein to a histone-modifying protein, scientists from Duke University, led by Isaac Hilton and Charles Gersbach, created a system that could selectively raise levels of gene expression by increasing activity at a variety of regulatory regions. Moreover, it was able to do so at high specificity with only a single guide RNA.

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Sep
12
Sponsored by
PerkinElmer

This webinar will cover recent advances in the use of CRISPR for generating animal models and cell lines.