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NEW YORK (GenomeWeb) – Scientists are using CRISPR/Cas9 genome editing to record a cell's history in its own DNA, answering questions such as where the cell came from in development, also known as cell lineage tracing, and what biochemical events it has encountered during its lifespan.

To trace cell lineage in early vertebrate development, Jay Shendure of the University of Washington and Alexander Schier of Harvard University led a team that created arrays of synthetic targets in the genome that could pick up different edits as the cells underwent ongoing rounds of division.

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