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NEW YORK – Researchers at Massachusetts General Hospital led by Keith Joung have found that adenine base editors (ABEs) and cytosine base editors (CBEs) that exhibit RNA off-target editing activity can also self-edit their own transcripts, leading to heterogeneity in base-editor coding sequences.

ABEs and CBEs are known to efficiently and precisely edit point mutations in DNA with minimal off-target DNA editing. However, recent studies have also shown that despite their reputations for generating low levels of off-target DNA edits, base editors may create unexpected problems.

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