CRISPR Researchers Engineer More Efficient Cas12a Variants for Genetic, Epigenetic, Base Editing

Feb 11, 2019

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NEW YORK (GenomeWeb) – In a study published today in Nature Biotechnology, researchers in Keith Joung's lab at Massachusetts General Hospital described their efforts to engineer enhanced variants of the Cas12a nuclease that can target a wider range of protospacer adjacent motifs (PAM), have enhanced editing activity, and have reduced off-target effects.

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