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NEW YORK – Three separate research teams have developed dual-deaminase CRISPR base editing platforms that combine the abilities of current adenine and cytosine base editors (ABEs and CBEs) to allow for concurrent A-to-G and C-to-T edits.

In papers published on Monday in Nature Biotechnology, teams led by Massachusetts General Hospital's J. Keith Joung, Dali Li of the East China Normal University in Shanghai, and the University of Tokyo's Nozomu Yachie each described their own approaches to the development of dual activity base editors.

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