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NEW YORK (GenomeWeb) – A team of Chinese researchers has found that CRISPR-based DNA base editors can induce tens of thousands of off-target mutations in RNA.

Adenine base editors (ABEs) and cytosine base editors (CBEs) are known to efficiently and precisely edit point mutations in DNA with minimal off-target DNA editing. However, recent studies have also shown that despite their reputations for generating low levels of off-target DNA edits, base editors may create unexpected problems.

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In PNAS this week: gene expression profiles of adipocyte subtypes, computational approach for improving plant expressome analysis, and more.

Aug
28
Sponsored by
Horizon Discovery

This webinar will provide an overview of alternatives to the popular Cas9 nuclease used in CRISPR gene editing.

Oct
23
Sponsored by
Swift Biosciences

This webinar will illustrate how single-cell methylation sequencing can be applied to gain significant insight into epigenetic heterogeneity in disease states, advancing cancer research discoveries.