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NEW YORK (GenomeWeb) – A team of Chinese researchers has found that CRISPR-based DNA base editors can induce tens of thousands of off-target mutations in RNA.

Adenine base editors (ABEs) and cytosine base editors (CBEs) are known to efficiently and precisely edit point mutations in DNA with minimal off-target DNA editing. However, recent studies have also shown that despite their reputations for generating low levels of off-target DNA edits, base editors may create unexpected problems.

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