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NEW YORK – An international research team led by Duke University's Charles Gersbach has found that class 1 CRISPR-Cas systems can be expressed in mammalian cells, and can also be used for DNA targeting and transcriptional control.

Class 2 CRISPR systems, such as Cas9 and Cas12, have been widely used to edit eukaryotic genomes, but class 1 systems represent about 90 percent of all CRISPR systems in nature and remain largely unexplored for genome engineering applications, the team noted.

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