Christiana Care Scientists Adapt Single-Nucleotide Editing Strategy for Use With CRISPR/Cas9 | GenomeWeb

NEW YORK (GenomeWeb) – CRISPR/Cas9 can help improve the efficiency of a method of single-nucleotide editing directed by single-stranded DNA oligos (ssODNs), according to studies published by scientists at Christiana Care Health System's Gene Editing Institute. While the method could help edit point mutations that cause human diseases, it is prone to leaving behind indels at the Cas9 cut site.

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