NEW YORK (GenomeWeb) – Broad Institute researcher David Liu and his colleagues have developed a Cas9 variant that is capable of recognizing a broader range of protospacer adjacent motif (PAM) sequences than the most commonly used Cas9 from Streptococcus pyogenes (SpCas9), while also achieving greater DNA specificity and substantially lower genome-wide off-target activity.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.

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With the Next Generation Sequencing (NGS), genomes sequencing has been democratized over the last decades with the detection of genomic alterations, thus replacing Sanger sequencing.