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NEW YORK (GenomeWeb) – Arrowhead Research announced that it has filed an investigational new drug application to begin two Phase IIb, multi-dose trials of its siRNA-based hepatitis B therapy ARC-520.

ARC-520 comprises two distinct siRNAs targeting highly conserved genomic regions across the major HBV genotypes, and is formulated with a proprietary delivery technology called dynamic polyconjugates. It is currently in a Phase IIa trial that is testing doses ranging from 1 mg/kg to 4 mg/kg in chronic HBV patients.

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