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Arrowhead Files to Begin Phase I Trial of HBV Drug

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Arrowhead Research said this week that it has filed an application with Australian regulators to begin phase I testing of its hepatitis B treatment ARC-520.

Arrowhead acquired the drug through its 2011 purchase of Roche’s RNA therapeutics assets (GSN 11/27/2011). It comprises cholesterol-conjugated siRNAs against HBV and a proprietary delivery technology called dynamic polyconjugates.

Earlier this year, Arrowhead’s president and CEO said that the company plans to run two phase I studies for ARC-520 — one in healthy patients in Australia and a second, to begin before the end of 2013, in HBV-infected patients in Hong Kong.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.