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NEW YORK – T cells isolated from the cerebrospinal fluid of people with multiple sclerosis express higher levels of genes linked to T cell activation and cytotoxicity than those from the CSF of healthy people, according to a new single-cell RNA sequencing study.

Despite the blood-brain and blood-cerebrospinal fluid barriers, T cells surveil the central nervous system via the CSF for pathogens. At the same time, however, they may contribute to neuroinflammation in conditions like MS.

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