NEW YORK (GenomeWeb) – Researchers from the Broad Institute and the Massachusetts Institute of Technology this week reported on a new technique that enables inducible gene editing and transcription modulation via CRISPR/Cas9.

CRISPR — short for clustered, regularly interspaced, short palindromic repeats — involves the use of a nuclease known as Cas9 to induce double-strand DNA breaks (DSBs). These breaks are targeted to specific locations in the genome using a synthetic RNA, known as a guide RNA, that directs Cas9.

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