Skip to main content
Premium Trial:

Request an Annual Quote

EU Kicks Off $15.9M Project to Investigate Cell Fate

NEW YORK (GenomeWeb News) – The 5-year, €12 million ($15.9 million) 4DCellFate project kicked off today aimed at investigating how the polycomb repressive complex (PRC) and nucleosome remodeling and histone deacetylase (NuRD) complexes function across the genome and time during differentiation.

The EU-funded project will apply technologies such as proteomics, high-throughput screening, structural biology, microscopy, and computational modeling to translate basic research findings into new research and medical solutions, CLC Bio, one of the partners in the project said.

"Understanding how the PRC and NuRD complexes determine cell fate is a prerequisite for developing models for diseases, such as cancer, that can be used both for further research and for developing personalized medicine therapies," Roald Forsberg, director of R&D at CLC, said in a statement.

Along with CLC, other partners in the project include the University of Cambridge; Fundació Privada Centre de Regulació Genòmica ; Copenhagen University; Universitair Medisch Centrum Utrecht; Universiteit Antwerpen; European Molecular Biology Laboratory; Max Planck Gesellschaft zur Förderung der Wissenschaften; Istituto Europeo di Oncologia; Horizon Discovery; Cellartis; and GlaxoSmithKline.

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.