NEW YORK (GenomeWeb News) – Researchers wanting to study human epigenomics may seek funding from The National Institutes of Health, which is supporting a program focused on discovering how changes in epigenetic profiles impact health with $6.7 million.
NIH expects to fund 10 to 15 studies with between $250,000 and $800,000 each for research that may illuminate the ways that epigenetic regulatory changes are causes or consequences of disease, aging, or environmental perturbation, and will discover epigenetic marks for various human disease states.
The multi-institute program, which is affiliated with the NIH Roadmap Epigenomics Program, will fund studies that use human cells or tissues that represent compromised, abnormal, or diseased states.
These disease states include epigenetic perturbations caused by exogenous exposure to dietary, chemical, social, or behavioral factors, abnormal regulation of fundamental processes during critical stages of life, and dysregulation of fundamental biological processes, such as inflammation, apoptosis, and oxidative stress.
These studies could include generation of genome-wide maps of epigenetic marks or other related regulatory elements, as well as mechanistic studies aimed at understanding the epigenetic differences between normal and diseased states. They also could include analysis of regions or patterns of DNA modifications, histone tail modifications, or other components of chromatin structure, non-coding RNAs or germ-line RNAs, among other areas.