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NEW YORK – A new epigenomic study of Clostridioides difficile has identified a highly conserved methyltransferase that may enable sporulation and could be targeted to treat infections.

C. difficile causes about half a million infections and 30,000 deaths each year and is one of the leading causes of hospital-acquired infections in the developed world. It spreads as spores, which can be resistant to many cleaning and disinfecting routines.

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The UK and the European Union have come to a sticking point in the negotiation of how the UK might remain involved in the Horizon Europe research program, the Guardian reports.

The New York Times reports that experts pushed during a meeting of an FDA advisory board for the agency to require more safety data from SARS-CoV-2 vaccine trials.

The Washington Post reports Moderna expects that it will have enough data on its candidate SARS-CoV-2 vaccine to submit to regulatory authorities by mid-November.

In Science this week: ANXA11 variants affect calcium homeostasis and stress granule disassembly in ALS, and more.