News on epigenetic profiling, DNA methylation, histone modifications, epigenetic disorders in genetics, genomics, and molecular diagnostics.
By bringing together epigenomic profiles for hundreds of tissue samples, researchers mapped regulatory modules relevant to a range of tissue and disease types.
The approach considers kinetic signals from the DNA polymerase used in PacBio sequencing, as well as the sequence context, to determine cytosine methylation sites.
The researchers developed a tissue map of the DNA 5hmC modification, finding a potential role for it in tissue-specific development.
NCI researchers performed a multi-platform study to elucidate the factors that can contribute to a patient's better-than-expected response to a drug.
At the ASHG 2020 virtual meeting, researchers presented data showing they could use the method to enrich for placental DNA in maternal plasma samples.
