News on epigenetic profiling, DNA methylation, histone modifications, epigenetic disorders in genetics, genomics, and molecular diagnostics.
A Lund University-led team developed two methylation risk scores to predict which patients would or would not respond to treatment and experience side effects.
Methylation profiles of more than 23,000 individuals uncovered thousands of epivariations, including some affecting Mendelian disease genes.
Researchers used the methylCIBERSORT algorithm to determine the makeup of the tumor immune microenvironment of about 6,000 pediatric central nervous system tumors.
The researchers proposed that increased NTRK2 regulation reduces memory formation, leading to a decreased PTSD risk among traumatized populations.
The researchers found that changes in histone modification at HPV integration events were correlated with upregulation of nearby genes and endogenous retroviruses.
