Skip to main content
Premium Trial:

Request an Annual Quote

Entelos to Evaluate Asthma Drug Candidates for Pfizer

NEW YORK, Dec. 13 – Biosimulation company Entelos has agreed to prioritize asthma drug candidates for Pfizer. 

Entelos of Menlo Park, Calif., said Wednesday it would use its Asthma PhysioLab technology to analyze how people with and without asthma react to the treatments and to determine the appropriate treatment dosages. 

Entelos will receive research funding and license fees from Pfizer as well as milestone payments for reaching particular objectives and novel findings and biomarkers.

"Over the last year, our capability and experience in applying in silico science and PhysioLab technology throughout the entire spectrum of drug discovery and development has increased tremendously,” James Karis, CEO of Entelos, said in a statement.

Entelos has developed a mathematical model of asthma in humans, which the company said it can use to simulate the disease as well as a patient’s responsiveness to drugs. Entelos said it can use its technology to identify novel pathways, speed up the drug development process, and better understand varying patient responsiveness to the treatments.

Entelos has PhysioLab systems for other diseases, including obesity, diabetes, and adipocytes.


The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.