Elucidating Medulloblastoma

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In Nature this week, researchers at the Broad Institute, and their collaborators in the US, Canada, and Germany report their whole-exome profiling of 92 medulloblastoma samples and paired normal samples, and their identification of 12 gene mutations they say occurred at statistically significant frequencies. These include both previously known mutations and newly identified recurrent somatic mutations in the RNA helicase gene DDX3X.

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