The approach, commonly used for genomics research, could prove effective for shotgun proteomics, as well, according to a paper byErasmusUniversityresearchers.
Exome sequencing of three family members with lung cancer revealed mutations in PARK2, a gene that codes for a ubiquitin ligase enzyme.
The funding will leverage genomics, informatics, and health information technologies to accelerate biomedical discoveries and yield more personalized medical treatments for patients in the US.
With eight independently programmable amplification wells, the firm's portable PCR platform is now in small-scale production.
The Centre for Evolutionary Genomics will train graduate students in genomic techniques, funded by a gift from the Leverhulme Trust's Doctoral Scholarships program.
The partners created a consortium that will perform a metagenomics study into the role that microorganisms play in a "normal, safe factory environment."
The 141-sample study found the test could identify benign lesions in lung cancer patients with a negative predictive value of between 84 percent and 98 percent.
BioJava 4.0.0 is available here. The release includes changes to the core application programming interface such as an improved GenBank parser and support for feature records, qualifiers, and nested locations. It also offers better support for crystallographic information, better organization of downloaded structure files, a new algorithm for symmetry detection in biological asesemblies, and other updates.
Affymetrix Founder and Chairman Stephen Fodor is retiring from the company's board, effective Jan. 30. Jami Nachtsheim will succeed Fodor as Chairwoman.
Fodor founded Affy in 1992 and initially was the company's scientific director. In 1993, he was named the firm's president and served as its CEO from 1997 to 2008. He has been on the board since Affy's founding and became its chairman in 1999.
Nachtsheim has been an Affy director since 2010. Three years later, she became its lead independent director.
Promega has released the PowerPlex Fusion 6C System for forensic casework samples. The PowerPlex Fusion 6C is a six-color, 27-locus multiplex system. It combines common and informative loci to overcome typical challenges faced by laboratories, including sample inhibitors, low levels of input DNA, degradation, and mixtures, Promega said. Two rapidly-mutating Y-STR loci, DYS570 and DYS576, are included in the multiplex for improved mixture interpretation, the firm said, and the system offers rapid-cycling protocols of approximately one hour.
New England Biolabs has introduced its NEBuilder HiFi DNA Assembly Cloning Kit and Master Mix for one-step cloning and multiple DNA fragment assembly in as little as 15 minutes. The proprietary DNA polymerase in the NEBuilder HiFi enzyme mix results in extremely accurate fragment assemblies and cloning junctions, and can assemble DNA fragments ranging from 100 bp to at least 19 kb, NEB said.
A University of Washington-led team looked at strain diversity in human gut microbiomes using a newly developed computational pipeline.