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Single-Cell Analysis of Colorectal Cancer Uncovers Two Epithelial-Cell Based Subtypes
The researchers further proposed a new classification system for the disease that includes epithelial subtype, microsatellite status, and whether fibrosis is present.
Spurred to Develop Again
New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.
The agency had originally planned to delete unspecified diagnosis codes for certain cancer tests covered under a national coverage decision.
PreventionGenetics Nabs FDA Approval for Obesity Drug Companion Diagnostic
The test detects variants in the POMC, PCSK1, and LEPR genes to identify individuals eligible for treatment with Rhythm Pharmaceuticals' recently approved Imcivree.
The company plans to launch a commercial product sometime after completing its currently ongoing Series A funding round.
Analysis of Tumor Mutation, Treatment Data Across Cancers Points to Predictive Biomarkers
With electronic health record and tumor panel sequence data from tens of thousands of cancer cases, researchers tallied relationships between gene alterations and patient outcomes.
Still Hanging Around
The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.
Through a Little Spit
Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.
MultiOmic Health, Mesh Bio Partner to Study Chronic Metabolic Disease for Drug, Dx Development
The companies will build a diverse research cohort with multiomics data and apply AI as they seek to improve diagnostics and advance drug discovery.
Becton Dickinson Gets CE-IVD Mark for BD Max Combined COVID, Flu, RSV Panel
The firm also plans to submit the assay to the US Food and Drug Administration for Emergency Use Authorization in the coming weeks.
Analysis of 7,500 patients showed one-third had potentially actionable mutations and 10 percent were misdiagnosed, prompting calls for greater NGS use in this setting.
Scientists from the University of Florence in Italy applied nanopore sequencing to effectively detect known copy number variants in a small cohort of patients.
Vaccine Update Recommended
A US Food and Drug Administration panel recommends booster vaccines be updated to target Omicron, CNBC reports.
US to Make More Vaccines for Monkeypox Available
The US is to make nearly 300,000 vaccine doses available in the coming weeks to stem the spread of human monkeypox virus, according to NPR.
Anitoa Systems Molecular Monkeypox Test Receives CE Mark
The PCR-based assay uses an extraction-free multiplex reagent to test orthopoxvirus and monkeypox gene targets in skin lesion samples.
Visby Medical Adds $35M to Series E Round
The San Jose, California-based infectious disease diagnostics company said it will use the funds to scale its production capacity and to add to its menu of tests.
NCI Names Participating Centers for Latest Clinical Proteomic Tumor Analysis Consortium Stage
The institute has awarded funding to a total of 12 sites to perform proteogenomic analyses on tumor samples and to study drug response and resistance.
mRNA-Based Vaccine on the Way in China
China may soon have its own mRNA-based vaccine, according to Nature News.
Boehringer Ingelheim, BiomX Embark on New Inflammatory Bowel Disease Biomarker Discovery Project
The deal is the second of its kind for the two companies following a 2020 partnership to investigate metagenomic markers of different IBD patient phenotypes.
PerkinElmer, Siemens Healthineers, SummerBio Lay Off Workers, Close Facilities
For PerkinElmer and SummerBio, the moves reflect weakening demand for COVID-19 testing, while the Siemens layoffs are linked to a manufacturing consolidation project.
Akoya Biosciences, Acrivon Therapeutics Partner to Develop CDx
The companies will codevelop, validate, and commercialize a companion diagnostic for Acrivon's targeted DNA damage response inhibitor therapy, ACR-368.
QIMR Berghofer Licenses Esophageal Cancer Blood Biomarkers to Proteomics International
Under the agreement, Proteomics International has the right to use the markers to develop and commercialize a blood-based early detection test for esophageal cancer.
Native Peruvian Genetic Ancestry Linked to Increased Risk of Tuberculosis Progression
The researchers conducted a longitudinal household contacts-based study of genetic ancestry and tuberculosis disease progression.
BforCure Gets CE Mark for 48-Well Flu/COVID Test Kit
The kit is provided in a 48-well microplate format and is compatible with automated reaction protocols.
Cue Health to Lay Off 170 People
The firm said it was laying off staff due to economic challenges and the US government's decision to reduce funding for COVID-19 testing.