The researchers further proposed a new classification system for the disease that includes epithelial subtype, microsatellite status, and whether fibrosis is present.
Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History
In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.
The method is available as a service from Single Cell Discoveries, and the researchers behind it are exploring several avenues of commercialization.
The method, which incorporates a background reduction step into the existing approach, reported higher on-target sequencing depth and end-to-end read length.
Researchers retraced historical migrations and relationships for Micronesian populations using genetic profiles for hundreds of ancient and modern individuals across the region.
The company plans to launch a commercial product sometime after completing its currently ongoing Series A funding round.
In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.
The effort generated one of the most expansive datasets to date linking protein expression to its genetic influences and provides a wealth of information for researchers.
Based on dozens of ancient wolf genomes, researchers detected genetic connectedness during the Ice Age and proposed at least two wolf sources of dog domestication.
In Genome Biology this week: proposed COVID-19 effector genes, method to predict transcription factor binding patterns, and more.
The institute has awarded funding to a total of 12 sites to perform proteogenomic analyses on tumor samples and to study drug response and resistance.
In PNAS this week: structural variants linked to blue cone monochromacy, HIV-1 variants affecting the matrix protein p17, and more.
The companies will codevelop, validate, and commercialize a companion diagnostic for Acrivon's targeted DNA damage response inhibitor therapy, ACR-368.
Under the agreement, Proteomics International has the right to use the markers to develop and commercialize a blood-based early detection test for esophageal cancer.
The researchers conducted a longitudinal household contacts-based study of genetic ancestry and tuberculosis disease progression.
In PLOS this week: link between breast cancer metastasis and CLIC4, sequencing analysis of left-sided cardiac defects, and more.
The method, called Pore-C, marries chromatin conformation capture with nanopore sequencing to directly detect 3D locus groupings across the entire genome.
The company has identified numerous immunogenic peptides derived from transposable elements at the surfaces of cancer cells.
Using a computational method called ASCEND, researchers retraced founder events in hundreds of modern and ancient human populations and dozens of dog breeds.
In Nature this week: pro-inflammatory microenvironment of epilepsy, clinical impact of pediatric molecular tumor profiling, and more.
An algorithm developed in Aviv Regev's lab and an algorithm developed for Fei Chen's Slide-seq were among the top performers, the study authors said.
Tissue gene expression and blood serum protein signatures distinguished between NAFLD patients with higher or lower risk of hepatocellular carcinoma development or recurrence.