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VizX Labs, BD Clontech, Corning, Applied Biosystems


VizX Labs has released a new version of its GeneSifter.Net, which allows users to access updated genomic data and statistical analysis by logging onto existing accounts.

The update includes analytic tools implemented using the standard “R” system, which comprises LOWESS normalization techniques, Holm and Bonferroni p-value correction methods, Welch’s t-test, and Kruskal-Wallis non-parametric tests; QuickLoad features tailored for import from a variety of microarray formats; and Dynamic Gene Ontology Navigation, which varies with different probe sets and grows over time with NCBI LocusLink, VizX said. This last addition enables researchers to automatically apply to their microarray research current knowledge of molecular function, cellular components, and biological process.

“As new biostatistical techniques emerge and open platforms such as R become scientific standards, we’re able to respond to our customers’ needs,” said Eric Olson, VizX Labs’ director of science.

BD Clontech has rolled out its Antibody Microarray 500, which enables researchers to assay more than 500 specific proteins.

The BD Biosciences unit said that scientists will be able to detect “a wide variety” of proteins, both cytosolic and membrane-bound, representing a broad range of biological functions including signal transduction, cell-cycle regulation, gene transcription, and apoptosis.

The fluorescence-based AB Array, as it is known, take less than one day to use and can help detect “as little as” 20 pg/ml of each protein target, BD said.

They are printed on glass slides and can be scanned by “most” commercial scanners.

Corning’s life-sciences business last week introduced the Pronto! cDNA and universal microarray-reagent systems for printing and hybridizing cDNA and long oligo arrays.

The Pronto! microarray-reagent systems can be used with Corning’s UltraGAPS slides, and can produce “highly reproducible results” with interslide CVs of 10 percent or less, Corning said.

“The consistency of results enables researchers to compare data between experiments and between slides,” the company explained; the system’s sensitivity “approaches” 0.5 pg per 5 µg of input total RNA, or between one and two copies per 500,000 cells.

The systems comprise kits for system validation, printing, and hybridization. Each system includes “all” the reagents and supplies users need to print or hybridize their microarrays in one convenient package, with the exception of labeling reagents.

Applied Biosystems named the members of a committee that will review entrants in a $250,000 SNP-genotyping grant program.

The committee will comprise: David Botstein, Stanford University; Kenneth Kidd, Yale University; Steve O'Brien, National Cancer Institute;

Jack Richards

, California Institute of Technology; Stefan Schreiber, University of Kiel, Germany; and John Todd, University of Cambridge.

As SNPtech Reporter reported Feb. 21, ABI said it intends to award $250,000 worth of its own SNP-genotyping products to the winner of the grant program it organized.

Proposals from individuals, institutions, and firms involved in SNP genotyping are welcome. Apply here:

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