The Underlying Biology


As a physician, Giuseppe Bianchi at San Raffaele Hospital in Milan finds it frustrating that he can only determine which antihypertensive drug will work in a given patient with a trial-and-error approach. Most of the available drugs only work in about 30 to 40 percent of the patient population, and those that do work affect the disease physiology, not the underlying molecular mechanisms. Bianchi, however, hopes to combine an understanding of the biological basis of the disease with genetic tools to find what drug works best in a particular patient.

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