Study of Protein Linked to Alzheimer's Gives Hope for Therapeutic | GenomeWeb

In an ongoing quest to find how exactly amyloid b protein is made from the amyloid precursor protein, researchers led by David Kang at the University of California, San Diego, have made a big step in the right direction. In a study published recently in the Journal of Biological Chemistry, Kang's team found that Ran-binding protein 9, RanBP9, plays a role by conjugating with another protein to form a scaffold that initiates the enzymatic cleavage of APP to Ab. The role of RanBP9, says Kang, could make it a possible new therapeutic target for Alzheimer's disease.

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