Study: Four Alleles Give Most Accurate Prognosis For Childhood Leukemia Yet | GenomeWeb

Four alleles in three genes identified in research in the upcoming issue of the journal Blood may serve as powerful prognostic markers for children with acute lymphoblastic leukemia following chemotherapy, while possibly providing drug makers with a new way to stratify clinical trials.

The suspect alleles are a non-null GSTM1 allele, the TYMS 3/3 allele, as well as two alleles of the VDR gene — the FokI and intron 8 polymorphisms.

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