Silent SNPs Aren’t So Mum On Drug Resistance, NCI Researchers Find | GenomeWeb
“Silent” polymorphisms, previously thought to have no functional effect, may play more of a role in drug resistance and response than scientists thought.
Researchers at the National Cancer Institute have recently discovered that SNPs in the multidrug resistance gene, or the MDR1 gene, can change a protein’s ability to bind to certain drugs without altering the protein’s sequence. 

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