Should Gene Expression-Based Prognostics Require More Patient Training Samples? | GenomeWeb

Prognostic tests such as Genomic Health's Oncotype Dx and Agendia's MammaPrint should be constructed using many more patient samples if they are to reach expected levels of reproducibility and test-to-test comparability, according to a recent study.

Moreover, one of the study authors said he believes regulatory bodies should develop requirements for the size of patient-sample populations for prognostic tests based on gene expression.

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The White House has created a list of cuts, including to the NIH, that could be in a budget bill for this year.

The US National Institutes of Health is to allow applicants to cite preprints just as they would any other research paper, ScienceInsider reports.

Two manuscript pages handwritten by Charles Darwin are going on the auction block, according to the Los Angeles Times.

In PNAS this week: tool to track transcriptome-wide binding, evidence of balancing selection on behavior-linked genes, and more.