Skip to main content
Premium Trial:

Request an Annual Quote

Sequenom Touts Tech in Diabetes Study

Premium

Sequenom said this week that its MassArray system has been used in the identification of a novel association between the HNF4A gene and type 2 diabetes, which was published in the April 2004 issue of Diabetes.

The study, entitled “Genetic Variation Near the Hepatocyte Nuclear Factor-4A Gene Predicts Susceptibility to Type 2 Diabetes,” was conducted by a team from the US, The UK, and Finland led by NHGRI director Francis Collins, as part of the Finland-United States Investigation Of NIDDM Genetics (FUSION) study. In this study, researchers are studying sibling pair families from Finland in an effort to identify genetic variants that predispose to type 2 diabetes.

The group surveyed a set of families and found a high degree of linkage on Chromosome 20, at 20q13. The group then used the MassArray to genotyped SNP markers in this area in pools of case and controls. The strongest association proved to be with a SNP 1.3 kb downstream of the primary ß-cell promoter P2 of HNF4A. They also found nine additional associated SNPS over 64 kb.

The Sequenom technology enabled the researchers to quickly profile between 30,000 and 100,000 SNPs, and narrow it down to two to five snps, then follow up with individual genotyping, said Robin Jackman, the company’s vice president of corporate development. “This gives you the power to reach much further than you would do normally if you were just doing pure genotyping,” he said.

Filed under

The Scan

White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds

A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.

Study Points to Benefits of Local Consolidative Therapy, Targeted Treatments in Cancer Care

In JCO Precision Oncology, researchers report that local consolidative therapy combined with molecularly targeted treatments could improve survival for some lung cancer patients.

Genetic Variants That Lower LDL Cholesterol Linked to Reduced Heart Disease Risk

Rare variants in two genes that lower LDL cholesterol are also associated with a decreased risk of coronary heart disease, according to a new JAMA Cardiology study.

Study Links Evolution of Longevity, Social Organization in Mammals

With the help of comparative phylogenetics and transcriptomics, researchers in Nature Communications see ties between lifespan and social organization in mammals.